E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation
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The E-Tmod-/- disease phenotype in cardiac morphogenesis. In a-c, the hearts of E-Tmod+/+ or E-Tmod+/- (top) and E-Tmod-/- (bottom) were compared. E9.5 embryos (a, see http://ajpheart.physiology.org/cgi/content/full/284/5/H1830/DC1 for a video showing peristaltic contractions of a normal heart tube and tremors of a E-Tmod-/- heart tube), the longitudinal midline sections of whole mount LacZ-stained tissue showing the developing heart (b), and cardiomyocytes in the ventricular wall (c) are compared.